Fluorinated NSC as a Cdc25 inhibitor

Hwangseo Park; Brian I Carr; Minghua Li; Seung Wook Ham

doi:10.1016/j.bmcl.2006.12.046

Fluorinated NSC as a Cdc25 inhibitor

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2351-4. doi: 10.1016/j.bmcl.2006.12.046. Epub 2006 Dec 21.

Authors

Hwangseo Park¹, Brian I Carr, Minghua Li, Seung Wook Ham

Affiliation

¹ Department of Bioscience and Biotechnology, Sejong University, 98 Kunja-Dong, Kwangjin-Ku, Seoul 143-747, Republic of Korea.

PMID: 17379514
DOI: 10.1016/j.bmcl.2006.12.046

Abstract

We report on the fluorinated form of NSC 95397 as a Cdc25B inhibitor, which is predicted to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Binding Sites
Cell Cycle Proteins / antagonists & inhibitors*
Chromogenic Compounds
Fluorine
Kinetics
Models, Molecular
Naphthoquinones / chemistry*
Naphthoquinones / pharmacology*
Protein Binding
Thermodynamics
cdc25 Phosphatases / antagonists & inhibitors*

Substances

2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone
Antineoplastic Agents
Cell Cycle Proteins
Chromogenic Compounds
Naphthoquinones
Fluorine
cdc25 Phosphatases